The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Dec. 04, 2009
Suhaib Siddiqi, Wakefield, MA (US);
J. William Efcavitch, San Carlos, CA (US);
Judith Mitchell, Brighton, MA (US);
Subramanian Marappan, Acton, MA (US);
Jayson Bowers, Cambridge, MA (US);
Mirna Jaroza, Arlington, MA (US);
Suhaib Siddiqi, Wakefield, MA (US);
J. William Efcavitch, San Carlos, CA (US);
Judith Mitchell, Brighton, MA (US);
Subramanian Marappan, Acton, MA (US);
Jayson Bowers, Cambridge, MA (US);
Mirna Jaroza, Arlington, MA (US);
Fluidigm Corporation, South San Francisco, CA (US);
Abstract
The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ψ-uridine.