The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Mar. 19, 2013
Applicant:
Council of Scientific & Industrial Research, New Delhi, IN;
Inventors:
Assignee:
Council of Scientific & Industrial Research, New Delhi, IN;
Primary Examiner:
Int. Cl.
CPC ...
C07F 7/02 (2006.01); C07F 7/18 (2006.01); C07D 215/20 (2006.01); C07D 215/38 (2006.01); C07D 471/06 (2006.01); C07D 217/16 (2006.01); C07D 217/22 (2006.01); C07D 217/24 (2006.01); C07D 491/056 (2006.01);
U.S. Cl.
CPC ...
C07F 7/1844 (2013.01); C07D 215/20 (2013.01); C07D 215/38 (2013.01); C07D 217/16 (2013.01); C07D 217/22 (2013.01); C07D 217/24 (2013.01); C07D 471/06 (2013.01); C07D 491/056 (2013.01);
Abstract
The present invention relates to novel and concise process for the construction of chiral 3-substituted tetrahyroquinoline derivatives based on proline catalyzed asymmetric α-functionalization of aldehyde, followed by in situ reductive cyclization of nitro group under catalytic hydrogenation condition with high optical purities. Further the invention relates to conversion of derived chiral 3-substituted tetrahydroquinoline derivatives into therapeutic agents namely (−)-sumanirole (96% ee) and 1-[(S)-3-(di-methylamino)-3,4-dihydro-6,7-dimethoxy-quinolin-1(2H)-yl]propanone[(S)-903] (92% ee).