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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9163038 B1

PDFFull Text
Expired
Date of Patent:
Oct. 20, 2015

Filed:

Mar. 19, 2013

Process for synthesis of chiral 3-substituted tetrahydroquinoline derivatives

Applicant:

Council of Scientific & Industrial Research, New Delhi, IN;

Inventors:

Varun Rawat, Pune, IN;

Senthil Kumar Boopathi, Pune, IN;

Arumugam Sudalai, Pune, IN;

Assignee:

Council of Scientific & Industrial Research, New Delhi, IN;

Attorneys:

Bret E. Field

Bozicevic, Field & Francis LLP

Primary Examiner:

Heidi Reese

Int. Cl.
CPC ...
C07F 7/02 (2006.01); C07F 7/18 (2006.01); C07D 215/20 (2006.01); C07D 215/38 (2006.01); C07D 471/06 (2006.01); C07D 217/16 (2006.01); C07D 217/22 (2006.01); C07D 217/24 (2006.01); C07D 491/056 (2006.01);
U.S. Cl.
CPC ...
C07F 7/1844 (2013.01); C07D 215/20 (2013.01); C07D 215/38 (2013.01); C07D 217/16 (2013.01); C07D 217/22 (2013.01); C07D 217/24 (2013.01); C07D 471/06 (2013.01); C07D 491/056 (2013.01);
Abstract

The present invention relates to novel and concise process for the construction of chiral 3-substituted tetrahyroquinoline derivatives based on proline catalyzed asymmetric α-functionalization of aldehyde, followed by in situ reductive cyclization of nitro group under catalytic hydrogenation condition with high optical purities. Further the invention relates to conversion of derived chiral 3-substituted tetrahydroquinoline derivatives into therapeutic agents namely (−)-sumanirole (96% ee) and 1-[(S)-3-(di-methylamino)-3,4-dihydro-6,7-dimethoxy-quinolin-1(2H)-yl]propanone[(S)-903] (92% ee).

Find Patent Forward Citations

Rawat, Varun. (2015). Process for synthesis of chiral 3-substituted tetrahydroquinoline derivatives (U.S. Patent No. 9163038). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9163038

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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