The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2015
Filed:
Sep. 24, 2010
Robert A. Mitchell, Louisville, KY (US);
John O. Trent, Louisville, KY (US);
Pooran Chand, Birmingham, AL (US);
Gilles Hugues Tapolsky, Louisville, KY (US);
Robert A. Mitchell, Louisville, KY (US);
John O. Trent, Louisville, KY (US);
Pooran Chand, Birmingham, AL (US);
Gilles Hugues Tapolsky, Louisville, KY (US);
University of Louisville Research Foundation, Inc., Louisville, KY (US);
Advanced Cancer Therapeutics, LLC, Louisville, KY (US);
Abstract
Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.