The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2015
Filed:
Feb. 06, 2014
Applicant:
The University of British Columbia, Vancouver, CA;
Inventors:
Assignee:
The University of British Columbia, Vancouver, British Columbia, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); G01N 33/50 (2006.01); A61K 31/70 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); G01N 33/5023 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2320/34 (2013.01); G01N 2800/2835 (2013.01);
Abstract
Methods and compositions for reducing expression of a mutant huntingtin (mHTT) protein in a cell are provided. Such methods include contacting the cell with an effective amount of a nucleic acid silencing agent targeting a differentiating polymorphism in RNA encoding the mHTT.