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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9157105 B1

PDFFull Text
Date of Patent:
Oct. 13, 2015

Filed:

Dec. 16, 2009

Biosynthesis of cmp-legionaminic acid from fructose-6-p, and respective pathway intermediates, using novel gdp-linked precursors

Applicants:

Ian C. Schoenhofen, Ottawa, CA;

Susan M. Logan, Ottawa, CA;

Inventors:

Ian C. Schoenhofen, Ottawa, CA;

Susan M. Logan, Ottawa, CA;

Assignee:

National Research Council of Canada, Ottawa, CA;

Attorneys:

Malcolm K. McGowan

Cermak Nakajima & McGowan LLP

Primary Examiner:

Susan Hanley

Int. Cl.
CPC ...
C12P 19/30 (2006.01); C12N 9/90 (2006.01); C12N 9/10 (2006.01); C12N 9/12 (2006.01); C12N 15/52 (2006.01); C12P 19/28 (2006.01); C12P 19/32 (2006.01);
U.S. Cl.
CPC ...
C12P 19/305 (2013.01); C12N 9/1048 (2013.01); C12N 9/12 (2013.01); C12N 9/90 (2013.01); C12N 15/52 (2013.01); C12P 19/28 (2013.01); C12P 19/32 (2013.01);
Abstract

The sialic acid-like sugar legionaminic acid is found as a virulence-associated surface glyco-conjugate inand. In this work, we have purified and biochemically characterized eleven candidate biosynthetic enzymes from, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. This pathway involves unique GDP-linked intermediates and provides a facile means for the efficient large-scale synthesis of an important sialic acid mimic and novel precursors.

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Schoenhofen, Ian. (2015). Biosynthesis of cmp-legionaminic acid from fructose-6-p, and respective pathway intermediates, using novel gdp-linked precursors (U.S. Patent No. 9157105). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9157105

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