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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9157084 B1

PDFFull Text
Date of Patent:
Oct. 13, 2015

Filed:

Dec. 20, 2010

Furin-knockdown bi-functional rna

Applicants:

John J. Nemunaitis, Cedar Hill, TX (US);

Neil Senzer, Dallas, TX (US);

Phillip B. Maples, Pilot Point, TX (US);

Donald Rao, Dallas, TX (US);

Inventors:

John J. Nemunaitis, Cedar Hill, TX (US);

Neil Senzer, Dallas, TX (US);

Phillip B. Maples, Pilot Point, TX (US);

Donald Rao, Dallas, TX (US);

Assignee:

GRADALIS, INC., Dallas, TX (US);

Attorneys:

Chalker Flores, LLP

Edwin S. Flores

Primary Examiner:

Richard Schnizer

Int. Cl.
CPC ...
C12N 15/00 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01); C12N 5/00 (2006.01); C12N 15/113 (2010.01); A61K 38/21 (2006.01); C07K 14/535 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 38/217 (2013.01); C07K 14/535 (2013.01); C12N 15/85 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2330/51 (2013.01); C12N 2830/20 (2013.01); C12N 2840/107 (2013.01);
Abstract

Compositions and methods to attenuate the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs was substituted therefor described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.

Find Patent Forward Citations

Nemunaitis, John. (2015). Furin-knockdown bi-functional rna (U.S. Patent No. 9157084). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9157084

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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