The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2015
Filed:
Jul. 07, 2009
Applicants:
Serge Muyldermans, Hoelaart, BE;
Viet Khong Nguyen, Hanoi, VN;
Inventors:
Serge Muyldermans, Hoelaart, BE;
Viet Khong Nguyen, Hanoi, VN;
Assignee:
VIB vzw, Zwijnaarde, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/30 (2006.01); C07K 16/00 (2006.01); C07K 16/24 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/005 (2013.01); C07K 16/241 (2013.01); C07K 16/3007 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/22 (2013.01); C07K 2317/56 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2319/22 (2013.01);
Abstract
The present invention relates to functional heavy chain antibodies, functional single domain heavy chain antibodies, functional VH domains, or functional fragments thereof comprising an amino acid which is neither a charged amino acid nor a C at position 45, and comprising an amino acid at position 103 independently chosen from the group consisting of R, G, K, S, Q, L, and P, and optionally an amino acid at position 108 independently chosen from the group consisting of Q, L and R, said positions determined according to the Kabat numbering.