The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 13, 2015

Filed:

Mar. 30, 2012
Applicants:

Harukazu Suzuki, Yokohama, JP;

Yuki Hasegawa, Yokohama, JP;

Alistair Forrest, Yokohama, JP;

Inventors:

Harukazu Suzuki, Yokohama, JP;

Yuki Hasegawa, Yokohama, JP;

Alistair Forrest, Yokohama, JP;

Assignee:

RIKEN, Saitama, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/10 (2006.01); C12N 1/00 (2006.01); C12N 5/073 (2010.01); C12N 15/09 (2006.01); C07K 14/52 (2006.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C07K 14/523 (2013.01); C07K 14/521 (2013.01); C12N 5/0696 (2013.01); C12N 2501/20 (2013.01); C12N 2501/235 (2013.01); C12N 2501/998 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present invention aims to provide a novel undifferentiated state-control agent that maintains and/or improves an undifferentiated state of undifferentiated cells. CCL2 or a protein containing a functional domain thereof is used as the undifferentiated state-control agent. By culturing undifferentiated cells in the presence of the control agent, it is possible to maintain and/or improve an undifferentiated state of the undifferentiated cells. Examples of the undifferentiated cells include embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells). The origin of the cells is not particularly limited, and may be a human, mouse, or the like, for example.


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