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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9156874 B1

PDFFull Text
Date of Patent:
Oct. 13, 2015

Filed:

Mar. 15, 2013

Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs

Applicant:

Nanjing Molecular Research, Inc., Nanjing, CN;

Inventors:

Junbiao Chang, Zhengzhou, CN;

Qiang Huang, Suzhou, CN;

Runcong Liu, Philadelphia, PA (US);

Zheng Wang, Suzhou, CN;

Assignee:

Nanjing Molecular Research, Inc., , CN;

Attorneys:

Fox Rothschild LLP

Wansheng Jerry Liu

Primary Examiner:

Patrick Lewis

Int. Cl.
CPC ...
A61K 31/70 (2006.01); A01N 43/04 (2006.01); C07H 19/10 (2006.01); C07H 19/12 (2006.01); C07H 19/20 (2006.01); C07F 9/6561 (2006.01); C07F 9/6558 (2006.01); C07H 19/06 (2006.01); C07H 19/073 (2006.01); C07H 19/09 (2006.01); C07H 19/16 (2006.01); C07H 19/173 (2006.01); C07H 19/19 (2006.01); C07H 19/207 (2006.01); C07D 405/04 (2006.01); C07D 473/34 (2006.01); C07D 473/40 (2006.01); C07F 9/26 (2006.01); C07F 9/24 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01); C07D 405/04 (2013.01); C07D 473/34 (2013.01); C07D 473/40 (2013.01); C07F 9/65586 (2013.01); C07F 9/65616 (2013.01); C07H 19/06 (2013.01); C07H 19/073 (2013.01); C07H 19/09 (2013.01); C07H 19/12 (2013.01); C07H 19/16 (2013.01); C07H 19/173 (2013.01); C07H 19/19 (2013.01); C07H 19/20 (2013.01); C07H 19/207 (2013.01); C07F 9/2429 (2013.01); C07F 9/26 (2013.01);
Abstract

This application discloses phosphoramidate and phosphonoamidate prodrugs of alcohol-based therapeutic agents, such as nucleosides, nucleotides, acyclonucleosides, C-nucleosides, and C-nucleotides, and use of these prodrugs for treatment of diseases or disorders, including infectious diseases and cancers. This application also discloses a general method for enhancing bioavailability and/or liver-targeting property of alcohol drugs through converting the alcohol drugs to phosphoramidate or phosphonoamidate prodrugs, and methods of preparation of these prodrugs.

Find Patent Forward Citations

Chang, Junbiao. (2015). Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs (U.S. Patent No. 9156874). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9156874

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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