The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2015
Filed:
Mar. 15, 2013
Applicant:
Nanjing Molecular Research, Inc., Nanjing, CN;
Inventors:
Junbiao Chang, Zhengzhou, CN;
Qiang Huang, Suzhou, CN;
Runcong Liu, Philadelphia, PA (US);
Zheng Wang, Suzhou, CN;
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); A01N 43/04 (2006.01); C07H 19/10 (2006.01); C07H 19/12 (2006.01); C07H 19/20 (2006.01); C07F 9/6561 (2006.01); C07F 9/6558 (2006.01); C07H 19/06 (2006.01); C07H 19/073 (2006.01); C07H 19/09 (2006.01); C07H 19/16 (2006.01); C07H 19/173 (2006.01); C07H 19/19 (2006.01); C07H 19/207 (2006.01); C07D 405/04 (2006.01); C07D 473/34 (2006.01); C07D 473/40 (2006.01); C07F 9/26 (2006.01); C07F 9/24 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01); C07D 405/04 (2013.01); C07D 473/34 (2013.01); C07D 473/40 (2013.01); C07F 9/65586 (2013.01); C07F 9/65616 (2013.01); C07H 19/06 (2013.01); C07H 19/073 (2013.01); C07H 19/09 (2013.01); C07H 19/12 (2013.01); C07H 19/16 (2013.01); C07H 19/173 (2013.01); C07H 19/19 (2013.01); C07H 19/20 (2013.01); C07H 19/207 (2013.01); C07F 9/2429 (2013.01); C07F 9/26 (2013.01);
Abstract
This application discloses phosphoramidate and phosphonoamidate prodrugs of alcohol-based therapeutic agents, such as nucleosides, nucleotides, acyclonucleosides, C-nucleosides, and C-nucleotides, and use of these prodrugs for treatment of diseases or disorders, including infectious diseases and cancers. This application also discloses a general method for enhancing bioavailability and/or liver-targeting property of alcohol drugs through converting the alcohol drugs to phosphoramidate or phosphonoamidate prodrugs, and methods of preparation of these prodrugs.