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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9156827 B1

PDFFull Text
Date of Patent:
Oct. 13, 2015

Filed:

Apr. 28, 2011

Anticancer agent

Applicants:

Tetsuo Nagano, Tokyo, JP;

Takayoshi Okabe, Ibaraki, JP;

Hirotatsu Kojima, Tokyo, JP;

Nae Saito, Tokyo, JP;

Hirofumi Nakano, Tokyo, JP;

Masanao Abe, Tokyo, JP;

Akiko Tanaka, Tokyo, JP;

Teruki Honma, Kanagawa, JP;

Shigeyuki Yokoyama, Tokyo, JP;

Keiko Tsuganezawa, Kanagawa, JP;

Hitomi Yuki, Kanagawa, JP;

Inventors:

Tetsuo Nagano, Tokyo, JP;

Takayoshi Okabe, Ibaraki, JP;

Hirotatsu Kojima, Tokyo, JP;

Nae Saito, Tokyo, JP;

Hirofumi Nakano, Tokyo, JP;

Masanao Abe, Tokyo, JP;

Akiko Tanaka, Tokyo, JP;

Teruki Honma, Kanagawa, JP;

Shigeyuki Yokoyama, Tokyo, JP;

Keiko Tsuganezawa, Kanagawa, JP;

Hitomi Yuki, Kanagawa, JP;

Assignees:

THE UNIVERSITY OF TOKYO, Tokyo, JP;

RIKEN, Saitama, JP;

Attorney:

Greenblum & Bernstein, P.L.C.

Primary Examiner:

David K O Dell

Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 31/36 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 405/06 (2006.01); C07D 493/04 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/36 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); C07D 405/06 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 493/04 (2013.01);
Abstract

An anticancer agent comprising a compound represented by the formula (I) [Rrepresents hydrogen atom, hydroxyl group, a Calkoxy group and the like; Rand Rrepresents hydrogen atom, a halogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group, a Calkylsulfonyl group and the like; Rrepresents hydrogen atom or a substituent;represents a single bond or a double bond; Rand Rrepresents hydrogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group and the like; A represents —O—, —S—, or —CH—; D represents —C═ or —N═; X represents methylene group, —O—, or —CO—; Q represents —N═ or —C(R)═; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

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