The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2015
Filed:
Apr. 13, 2012
Wanggui Yang, Hong Kong, HK;
Yi Wong, Hong Kong, HK;
Olivia T. W. NG, Hong Kong, HK;
Hung Wing LI, Hong Kong, HK;
Ken K. L. Yung, Hong Kong, HK;
Daniel W. J. Kwong, Hong Kong, HK;
Ricky M. S. Wong, Hong Kong, HK;
Wanggui Yang, Hong Kong, HK;
Yi Wong, Hong Kong, HK;
Olivia T. W. Ng, Hong Kong, HK;
Hung Wing Li, Hong Kong, HK;
Ken K. L. Yung, Hong Kong, HK;
Daniel W. J. Kwong, Hong Kong, HK;
Ricky M. S. Wong, Hong Kong, HK;
HONG KONG BAPTIST UNIVERSITY, Kowloon Tong, Kowloon, HK;
Abstract
The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.