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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9156814 B1

PDFFull Text
Date of Patent:
Oct. 13, 2015

Filed:

Apr. 13, 2012

Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation

Applicants:

Wanggui Yang, Hong Kong, HK;

Yi Wong, Hong Kong, HK;

Olivia T. W. NG, Hong Kong, HK;

Hung Wing LI, Hong Kong, HK;

Ken K. L. Yung, Hong Kong, HK;

Daniel W. J. Kwong, Hong Kong, HK;

Ricky M. S. Wong, Hong Kong, HK;

Inventors:

Wanggui Yang, Hong Kong, HK;

Yi Wong, Hong Kong, HK;

Olivia T. W. Ng, Hong Kong, HK;

Hung Wing Li, Hong Kong, HK;

Ken K. L. Yung, Hong Kong, HK;

Daniel W. J. Kwong, Hong Kong, HK;

Ricky M. S. Wong, Hong Kong, HK;

Assignee:

HONG KONG BAPTIST UNIVERSITY, Kowloon Tong, Kowloon, HK;

Attorneys:

Ella Cheong Hong Kong

Sam T. Yip

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Jagadishwar Samala

Int. Cl.
CPC ...
A61K 49/10 (2006.01); A61K 49/00 (2006.01); C07D 401/06 (2006.01); A61K 49/08 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/473 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); A61K 31/4439 (2013.01); A61K 31/473 (2013.01); A61K 31/4709 (2013.01); A61K 49/0002 (2013.01); A61K 49/0021 (2013.01); A61K 49/0026 (2013.01); A61K 49/085 (2013.01); A61K 49/10 (2013.01);
Abstract

The present invention relates to methods of detecting and monitoring aggregation of beta-amyloid peptides which are associated with neurodegenerative diseases as well as treating and/or preventing the neurodegenerative diseases by using carbazole-based fluorophores. In particular, the present invention provides methods for labeling and imaging the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and/or in vivo, as well as treating and/or preventing Alzheimer's disease by using the carbazole-based fluorophores of the present invention.

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Yang, Wanggui. (2015). Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation (U.S. Patent No. 9156814). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9156814

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