The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 13, 2015

Filed:

May. 07, 2009
Applicants:

Vincent C. O. Njar, Lansdale, PA (US);

Lalji K. Gediya, Secane, PA (US);

Aakanksha Khandelwal, Silver Spring, MD (US);

Inventors:

Vincent C. O. Njar, Lansdale, PA (US);

Lalji K. Gediya, Secane, PA (US);

Aakanksha Khandelwal, Silver Spring, MD (US);

Assignee:

UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4164 (2006.01); A61K 31/53 (2006.01); A61K 31/4196 (2006.01); A61K 31/41 (2006.01); A61K 31/519 (2006.01); C07D 233/60 (2006.01); C07D 487/04 (2006.01); C07D 251/02 (2006.01); C07D 221/04 (2006.01); C07D 249/02 (2006.01); C07D 233/56 (2006.01);
U.S. Cl.
CPC ...
C07D 233/56 (2013.01); A61K 31/41 (2013.01); A61K 31/4164 (2013.01); A61K 31/4196 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); C07D 233/60 (2013.01); C07D 249/02 (2013.01); C07D 251/02 (2013.01); C07D 487/04 (2013.01);
Abstract

Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the presence of suitable coupling reagents. The retinamide RAMBAs are potent inhibitors of the growth of prostate and breast cancer cells and may be useful for the treatment of these diseases in humans.


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