The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 13, 2015

Filed:

Dec. 16, 2013
Applicants:

Shoujun Chen, Bedford, MA (US);

Keizo Koya, Chestnut Hill, MA (US);

Zachary Demko, San Francisco, CA (US);

Lijun Sun, Harvard, MA (US);

Inventors:

Shoujun Chen, Bedford, MA (US);

Keizo Koya, Chestnut Hill, MA (US);

Zachary Demko, San Francisco, CA (US);

Lijun Sun, Harvard, MA (US);

Assignee:

Synta Pharmaceuticals Corp., Lexington, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/15 (2006.01); C07C 243/14 (2006.01); C07C 243/42 (2006.01); C07C 327/56 (2006.01); C07C 243/28 (2006.01); C07C 255/66 (2006.01); C07C 257/22 (2006.01); C07C 261/04 (2006.01); C07C 281/06 (2006.01); C07C 307/04 (2006.01); C07C 311/49 (2006.01); C07C 311/51 (2006.01); C07C 337/06 (2006.01); C07D 207/34 (2006.01); C07D 207/36 (2006.01); C07D 233/74 (2006.01); C07D 263/48 (2006.01); C07D 271/10 (2006.01); C07D 271/113 (2006.01); C07D 307/66 (2006.01); C07F 9/44 (2006.01); A61K 31/16 (2006.01); A61K 31/166 (2006.01); A61K 31/18 (2006.01); A61K 31/277 (2006.01); A61K 31/341 (2006.01); A61K 31/40 (2006.01); A61K 31/4245 (2006.01); A61K 31/664 (2006.01); C07C 243/34 (2006.01); C07C 311/55 (2006.01); C07F 9/22 (2006.01); C07F 9/46 (2006.01);
U.S. Cl.
CPC ...
C07C 327/56 (2013.01); A61K 31/16 (2013.01); A61K 31/166 (2013.01); A61K 31/18 (2013.01); A61K 31/277 (2013.01); A61K 31/341 (2013.01); A61K 31/40 (2013.01); A61K 31/4245 (2013.01); A61K 31/664 (2013.01); C07C 243/28 (2013.01); C07C 243/34 (2013.01); C07C 255/66 (2013.01); C07C 257/22 (2013.01); C07C 261/04 (2013.01); C07C 281/06 (2013.01); C07C 307/04 (2013.01); C07C 311/49 (2013.01); C07C 311/51 (2013.01); C07C 311/55 (2013.01); C07C 337/06 (2013.01); C07D 207/34 (2013.01); C07D 207/36 (2013.01); C07D 233/74 (2013.01); C07D 263/48 (2013.01); C07D 271/10 (2013.01); C07D 271/113 (2013.01); C07D 307/66 (2013.01); C07F 9/228 (2013.01); C07F 9/4423 (2013.01); C07F 9/4496 (2013.01); C07F 9/46 (2013.01); C07C 2101/02 (2013.01);
Abstract

Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.


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