The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2015
Filed:
Jul. 11, 2011
Martina Eichenberger, Brig-Glis, CH;
Paul Hanselmann, Brig-Glis, CH;
Florencio Zaragoza Dörwald, Visp, CH;
Martina Eichenberger, Brig-Glis, CH;
Paul Hanselmann, Brig-Glis, CH;
Florencio Zaragoza Dörwald, Visp, CH;
LONZA LTD, Visp, CH;
Abstract
Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein Ris Calkyl, Rand Rare independently hydrogen or fluorine, M is an alkali or alkaline earth metal, and n is 1 or 2, are prepared from enolate salts of the corresponding 4-fluoro-3-oxobutyrates and carbon monoxide. The enolate salts of formula I can be alkylated or acylated to obtain the corresponding enol ethers and esters. The 4-fluoro-3-oxobutyrate starting material can be prepared from 1,1-difluoroethyl methyl ethers by SbF-catalyzed fluoromethane elimination followed by halogen exchange with lithium chloride, reacting the thus obtained fluoroacetyl chloride with ketene and quenching with the appropriate alcohol R—OH.