The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Nov. 03, 2008
Sine Reker-hadrup, Virum, DK;
Arnold Hendrik Bakker, Berkeley, CA (US);
Cheng Yi Jenny Shu, Boston, MA (US);
Antonius Nicolaas Maria Schumacher, Haarlem, NL;
Sine Reker-Hadrup, Virum, DK;
Arnold Hendrik Bakker, Berkeley, CA (US);
Cheng Yi Jenny Shu, Boston, MA (US);
Antonius Nicolaas Maria Schumacher, Haarlem, NL;
Stichting Sanquin Bloedvoorziening, Amsterdam, NL;
Stichting het Nederlands Kanker Instituut, Amsterdam, NL;
Abstract
The present invention relates to methods for detecting antigen responsive cells in a sample using multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (NHC). Further, the present invention relates to the use of the present multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (MHC), for detecting antigen responsive cells in a sample, preferably a single sample, such as a blood sample. The present method allows high-throughput analysis of specific antigen responsive cells, such as T- and B-cells, thereby providing, for example, high-throughput methods for monitoring of diseases or conditions and the development of immunotherapeutics, vaccines, or the identification epitopes or immunogenic amino acid sequences.