The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2015

Filed:

Aug. 27, 2013
Applicants:

Anja Smith, Thronton, CO (US);

Angela Reynolds, Littleton, CO (US);

Jon E. Chatterton, Fort Worth, TX (US);

Xinyu Zhang, Southlake, TX (US);

Inventors:

Anja Smith, Thronton, CO (US);

Angela Reynolds, Littleton, CO (US);

Jon E. Chatterton, Fort Worth, TX (US);

Xinyu Zhang, Southlake, TX (US);

Assignees:

Thermo Fisher Scientific Inc., Waltham, MA (US);

Arrowhead Research Corporation, Madison, WI (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1136 (2013.01); A61K 31/713 (2013.01); C12N 2310/14 (2013.01);
Abstract

Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression.


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