The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Aug. 28, 2009
Applicant:
Michael Paul Jennings, Brisbane, AU;
Inventor:
Michael Paul Jennings, Brisbane, AU;
Assignee:
The University of Queensland, Queensland, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/22 (2006.01); A61K 39/095 (2006.01); A61K 38/00 (2006.01); C07K 16/22 (2006.01); C12N 9/06 (2006.01); C07K 16/12 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/22 (2013.01); A61K 39/095 (2013.01); C07K 16/1217 (2013.01); C12N 9/0044 (2013.01); C12P 21/005 (2013.01); C12Y 107/02001 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to the use of mutant glycoproteins from pathogenic bacteria lacking one or more phosphorylcholine and/or glycosylation post-translational modifications as immunogens. These post-translational modifications act as masking structures that elicit an immune response which does not confer protection on an infected individual. The removal or modification of these masking structures alters the protein such that it elicits a stronger immune response to the protein and/or the bacterial pathogen. Particular examples are pilin proteins and nitrite reductase glycoproteins ofbacteria.