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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9150610 B1

PDFFull Text
Date of Patent:
Oct. 06, 2015

Filed:

Nov. 16, 2010

Method and apparatus to perform hydrogen-deuterium exchange

Applicants:

Thorleif Lavold, Stockholm, SE;

Juan Astorga Wells, Johanneshov, SE;

Inventors:

Thorleif Lavold, Stockholm, SE;

Juan Astorga Wells, Johanneshov, SE;

Assignee:

BIOMOTIF AB, Taby, SE;

Attorneys:

Carter, DeLuca, Farrell & Schmidt, LLP

Robert P. Michal, Esq.

Primary Examiner:

Jennifer Wecker

Int. Cl.
CPC ...
G01N 27/26 (2006.01); G01N 30/04 (2006.01); G01N 30/00 (2006.01); C07K 1/13 (2006.01); G01N 30/72 (2006.01); G01N 30/06 (2006.01); G06F 19/00 (2011.01); G01N 30/02 (2006.01); H01J 49/00 (2006.01); H01J 49/04 (2006.01); G01N 30/96 (2006.01); B01D 15/36 (2006.01); H01J 49/16 (2006.01); G01N 1/40 (2006.01); G01N 30/14 (2006.01);
U.S. Cl.
CPC ...
C07K 1/13 (2013.01); G01N 30/06 (2013.01); G01N 30/7266 (2013.01); G06F 19/703 (2013.01); B01D 15/361 (2013.01); G01N 27/26 (2013.01); G01N 30/00 (2013.01); G01N 30/96 (2013.01); G01N 2001/4011 (2013.01); G01N 2001/4016 (2013.01); G01N 2030/067 (2013.01); G01N 2030/146 (2013.01); H01J 49/00 (2013.01); H01J 49/0018 (2013.01); H01J 49/04 (2013.01); H01J 49/0431 (2013.01); H01J 49/165 (2013.01); Y10T 436/24 (2015.01);
Abstract

Apparatus and methods to perform hydrogen/deuterium exchange using semipermeable membranes are described. The system has two channels separated by a semipermeable membrane. One channel comprises a flow carrying the analyte of interest, and the second channel comprises a solution comprising a deuterated solvent (e.g. deuterium oxide). The system does not require an external electric field gradient across the membrane to perform the hydrogen-deuterium exchange procedure. The present invention facilitates sample and reagent handling as well as simplifies manufacture of devices and/or instrumentation related to deuterium exchange. Further described is a chemical analyzation device for analyzing chemical compositions and/or compounds, and a method for analyzing chemical compounds and a computer program product for inducing a computer to perform steps in the method. Also described is a method for analyzing interactions between analytes and charged molecules, and calculating binding coefficients of the analytes with respect to the charged molecules.

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