The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Jul. 24, 2012
Show-wen Liu, Taoyuan County, TW;
Yu Chang, Taoyuan County, TW;
Cheng-fang Hsu, Taoyuan County, TW;
Ming-che Tsai, Taoyuan County, TW;
Tsung-hsien Chiang, Taoyuan County, TW;
Yueh-feng Deng, Taoyuan County, TW;
Kuei-lin LU, Taoyuan County, TW;
Chih-yuan Lin, Taoyuan County, TW;
Da-ming Wang, Taoyuan County, TW;
Ching-yun LI, Taoyuan County, TW;
Show-Wen Liu, Taoyuan County, TW;
Yu Chang, Taoyuan County, TW;
Cheng-Fang Hsu, Taoyuan County, TW;
Ming-Che Tsai, Taoyuan County, TW;
Tsung-Hsien Chiang, Taoyuan County, TW;
Yueh-Feng Deng, Taoyuan County, TW;
Kuei-Lin Lu, Taoyuan County, TW;
Chih-Yuan Lin, Taoyuan County, TW;
Da-Ming Wang, Taoyuan County, TW;
Ching-Yun Li, Taoyuan County, TW;
Atomic Energy Council, Institute of Nuclear Energy Research, Taoyuan County, TW;
Abstract
A precursor used for labeling hepatocyte receptors and applied to radiotracers for imaging or pharmaceutical compositions for liver cancers is revealed. The precursor is a bifunctional compound. The bifunctional group includes a trisaccharide structure and a diamide dimercaptide (NS) ligand. The trisaccharide has high affinity to asialoglycoprotein receptors (ASGPR) on surfaces of hepatocytes while NSligand reacts with radioisotopes to form neutral complexes. Thus the precursor stays on surfaces of hepatocytes to provide radioisotope labeling or treatment effect of liver cancers.