The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2015

Filed:

Dec. 06, 2012
Applicant:

Research Triangle Institute, Research Triangle Park, NC (US);

Inventors:

Scott Runyon, Hillsborough, NC (US);

Yanan Zhang, Apex, NC (US);

Carla Hassler, Durham, NC (US);

Brian Gilmour, Mebane, NC (US);

Assignee:

RESEARCH TRIANGLE INSTITUTE, Research Triangle Park, NC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/04 (2006.01); A61K 31/4355 (2006.01); C07D 491/048 (2006.01); C07D 491/10 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); C07D 491/04 (2013.01); C07D 491/10 (2013.01); C07D 491/107 (2013.01);
Abstract

Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.


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