The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2015

Filed:

Mar. 04, 2011
Applicants:

Zhiwei Jiang, Zhejiang, CN;

Aijin Wang, Zhejiang, CN;

Hongwei HU, Zhejiang, CN;

Jiali Xu, Zhejiang, CN;

Yuesong HU, Zhejiang, CN;

Xian LI, Zhejiang, CN;

Yan YE, Zhejiang, CN;

Jie Wang, Zhejiang, CN;

Qinglong LI, Zhejiang, CN;

Inventors:

Zhiwei Jiang, Zhejiang, CN;

Aijin Wang, Zhejiang, CN;

Hongwei Hu, Zhejiang, CN;

Jiali Xu, Zhejiang, CN;

Yuesong Hu, Zhejiang, CN;

Xian Li, Zhejiang, CN;

Yan Ye, Zhejiang, CN;

Jie Wang, Zhejiang, CN;

Qinglong Li, Zhejiang, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/34 (2006.01); C07D 307/92 (2006.01); A61K 31/343 (2006.01); A61K 31/665 (2006.01); A61K 45/06 (2006.01); C07F 9/655 (2006.01);
U.S. Cl.
CPC ...
C07D 307/92 (2013.01); A61K 31/343 (2013.01); A61K 31/665 (2013.01); A61K 45/06 (2013.01); C07F 9/65517 (2013.01);
Abstract

The present invention discloses esters of 4,9-dihydroxy-naphtho[2,3-b]furans and methods of making and using the same. The present invention also discloses conversion of the esters into therapeutically active 4,9-dihydroxy-naphtho[2,3-b]furans in vivo. The present invention furthermore discloses pharmaceutical compositions comprising the esters of 4,9-dihydroxy-naphtho[2,3-b]furans for the treatment of various indications including proliferative diseases.


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