The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Jul. 05, 2012
Roberto Adamo, Siena, IT;
Martin Allen, Cambridge, MA (US);
Francesco Berti, Siena, IT;
Elisa Danieli, Siena, IT;
Qi-ying HU, Cambrdige, MA (US);
Roberto Adamo, Siena, IT;
Martin Allen, Cambridge, MA (US);
Francesco Berti, Siena, IT;
Elisa Danieli, Siena, IT;
Qi-Ying Hu, Cambrdige, MA (US);
NOVARTIS AG, Basel, CH;
Abstract
A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having and amino terminus end (A) and an acid terminus end (A) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.