The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2015

Filed:

Mar. 26, 2010
Applicants:

Michael Chopp, Southfield, MI (US);

Zhenggang Zhang, Troy, MI (US);

Daniel C. Morris, Grosse Point Park, MI (US);

Inventors:

Michael Chopp, Southfield, MI (US);

Zhenggang Zhang, Troy, MI (US);

Daniel C. Morris, Grosse Point Park, MI (US);

Assignee:

HENRY FORD HEALTH SYSTEM, Detroit, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61P 25/32 (2006.01); A61K 38/22 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2292 (2013.01);
Abstract

Thymosin β4 can be used to treat neuronal and brain injuries that are accompanied by neuronal cell death or injury, including injuries caused by stroke or trauma and injuries caused by neurological and neurodegenerative disease. In particular, stroke and multiple sclerosis are examples of conditions which may be ameliorated by treatment with thymosin β4. Thymosin β4 has been found to restore neurological tissue through several effects on several neurological parameters which are improved by administration of thymosin β4 to a subject in need of neurological tissue restoration. For example, thymosin β4 improves axonal myelination, migration of neural progenitor cells, neural progenitor cell proliferation, differentiation of neural progenitor cells into mature neurons, differentiation of neural progenitor cells into mature glia, nerve regeneration, and brain remodeling at locations of brain injury.


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