The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2015
Filed:
Sep. 11, 2013
Applicant:
Trustees of Dartmouth College, Hanover, NH (US);
Inventors:
Ta-Yuan Chang, Etna, NH (US);
Catherine C. Y. Chang, Etna, NH (US);
Yohei Shibuya, West Lebanon, NH (US);
Elena Bryleva, Lebanon, NH (US);
Stephanie Murphy, West Lebanon, NH (US);
Maximillian A. Rogers, White River Junction, VT (US);
Assignee:
Trustees of Dartmouth College, Hanover, NH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/713 (2006.01); A61K 9/00 (2006.01); A61K 31/44 (2006.01); A61K 31/255 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7105 (2006.01); C12N 15/113 (2010.01); A61K 31/167 (2006.01); A61K 31/395 (2006.01); A61K 31/415 (2006.01); A61K 31/496 (2006.01); A61K 31/55 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 9/00 (2013.01); A61K 9/5184 (2013.01); A61K 31/00 (2013.01); A61K 31/167 (2013.01); A61K 31/255 (2013.01); A61K 31/395 (2013.01); A61K 31/415 (2013.01); A61K 31/44 (2013.01); A61K 31/496 (2013.01); A61K 31/55 (2013.01); A61K 31/70 (2013.01); A61K 31/7105 (2013.01); C12N 15/1137 (2013.01); C12Y 203/01009 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01);
Abstract
The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.