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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9145565 B1

PDFFull Text
Date of Patent:
Sep. 29, 2015

Filed:

Dec. 08, 2011

Targeted chromosomal mutagenesis using zinc finger nucleases

Applicants:

Dana Carroll, Salt Lake City, UT (US);

Mary M. Golic, Salt Lake City, UT (US);

Marina Bibikova, San Diego, CA (US);

Gary Drews, Salt Lake City, UT (US);

Kent G. Golic, Salt Lake City, UT (US);

Inventors:

Dana Carroll, Salt Lake City, UT (US);

Mary M. Golic, Salt Lake City, UT (US);

Marina Bibikova, San Diego, CA (US);

Gary Drews, Salt Lake City, UT (US);

Kent G. Golic, Salt Lake City, UT (US);

Assignee:

University of Utah Research Foundation, Salt Lake City, UT (US);

Attorney:

Ballard Spahr LLP

Primary Examiner:

Cynthia Collins

Int. Cl.
CPC ...
C12N 15/90 (2006.01); A01K 67/033 (2006.01); C12N 9/22 (2006.01); C12N 15/82 (2006.01);
U.S. Cl.
CPC ...
C12N 15/902 (2013.01); A01K 67/0339 (2013.01); C12N 9/22 (2013.01); C12N 15/8213 (2013.01);
Abstract

The present invention provides for a method or methods of targeted genetic recombination or mutagenesis in a host cell or organism, and compositions useful for carrying out the method. The targeting method of the present invention exploits endogenous cellular mechanisms for homologous recombination and repair of double stranded breaks in genetic material. The present invention provides numerous improvements over previous mutagenesis methods, such advantages include that the method is generally applicable to a wide variety of organisms, the method is targeted so that the disadvantages associated with random insertion of DNA into host genetic material are eliminated, and certain embodiments require relatively little manipulation of the host genetic material for success. Additionally, it provides a method that produces organisms with specific gene modifications in a short period of time.

Find Patent Forward Citations

Carroll, Dana. (2015). Targeted chromosomal mutagenesis using zinc finger nucleases (U.S. Patent No. 9145565). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9145565

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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