The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2015
Filed:
May. 30, 2012
Luz Amalia Rios Vasquez, Manizales, CO;
Rogelio Ocampo Cardona, Manizales, CO;
Sandra Milena Duque, Manizales, CO;
Sara Maria Robledo Restrepo, Medellin, CO;
Ivan Dario Velez Bernal, Medellin, CO;
David Leonardo Cedeño Medina, Normal, IL (US);
Marjorie Ann Jones, Carlock, IL (US);
Luz Amalia Rios Vasquez, Manizales, CO;
Rogelio Ocampo Cardona, Manizales, CO;
Sandra Milena Duque, Manizales, CO;
Sara Maria Robledo Restrepo, Medellin, CO;
Ivan Dario Velez Bernal, Medellin, CO;
David Leonardo Cedeño Medina, Normal, IL (US);
Marjorie Ann Jones, Carlock, IL (US);
UNIVERSIDAD DE CALDAS, Caldas, CO;
UNIVERSIDAD DE ANTIOQUIA, Antioquia, CO;
THE BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY, Normal, IL (US);
Abstract
The use of quaternary halogenated ammonium salts for treating leishmaniasis infections and other parasitic diseases is described. Although there have been previous reports in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of such salts containing a halogenated N-methyl substituent as a therapeutic agent against leishmaniasis had not been reported. The compounds described here, in specific those with a terminal arylalkenyl or diarylalkenyl moiety, are shown to inhibit the growth ofparasites, a known causative agent of leishmaniasis disease. In addition, the series of compounds are also extensive against malaria, Chagas disease, toxoplasmosis, and other parasitic diseases.