The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2015
Filed:
Oct. 01, 2013
Applicant:
Saint Louis University, St. Louis, MO (US);
Inventors:
Rajeev Aurora, Wildwood, MO (US);
Zachary Buchwald, St. Louis, MO (US);
Jennifer Kiesel, Pacific, MO (US);
Assignee:
Saint Louis University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 38/19 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
A61K 38/191 (2013.01); A61K 38/178 (2013.01); A61K 35/17 (2013.01);
Abstract
Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (Tc). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (Tc) either in vivo or ex vivo. The FoxP3+ CD8 T-cells (Tc) are provided to the patient to subsequently regulate osteoclast function, thereby establishing a bi-directional regulatory loop between osteoclasts and FoxP3+ CD8 T-cells (Tc).