The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2015
Filed:
Mar. 25, 2014
Applicant:
Synageva Biopharma Corp., Lexington, MA (US);
Inventors:
Assignee:
Synageva BioPharma Corp., Lexington, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 15/00 (2006.01); A01K 67/027 (2006.01); C07K 16/02 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); C07K 16/02 (2013.01); C12N 15/8509 (2013.01); A01K 2217/052 (2013.01); A01K 2227/30 (2013.01); A01K 2267/01 (2013.01); C07K 2317/11 (2013.01); C07K 2317/732 (2013.01); C07K 2317/77 (2013.01);
Abstract
Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of transgene-derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems.