The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Dec. 06, 2012
Baxter International Inc., Deerfield, IL (US);
Baxter Healthcare S.a., Glattpark (Opfikon), CH;
John A. Baugh, Kilpedder, IE;
Richard J. Bucala, Cos Cob, CT (US);
Smita Chitnis, San Diego, CA (US);
Seamus C. Donnelly, Dublin, IE;
Peter K. Gregersen, Larchmont, NY (US);
Joanita Monteiro, Philadelphia, PA (US);
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta GmbH, Glattpark (Opfikon), CH;
Abstract
Describe herein is a novel CATT-tetranucleotide repeat polymorphism at position −817 of the human Mif that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-CATT repeat units. Of these, the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients. Methods, compositions and apparatus for detecting this CATT-tetranucleotide repeat polymorphism at position −817 of the human Mif gene, and for using same for assessing predisposition to severe inflammatory disease, are also disclosed.