The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Mar. 12, 2013
Applicant:
Arrowhead Research Corporation, Pasadena, CA (US);
Inventors:
Assignee:
Arrowhead Research Corporation, Pasadena, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1131 (2013.01); A61K 31/711 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/322 (2013.01); C12N 2310/334 (2013.01); C12N 2310/335 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/53 (2013.01);
Abstract
The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer.