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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9139703 B1

PDFFull Text
Date of Patent:
Sep. 22, 2015

Filed:

Oct. 15, 2010

Method of solubilizing poorly soluble/insoluble active material through formation of oligomer composite

Applicants:

Chul-hwan Kim, Daejeon, KR;

Seung-hak Ko, Gunsan-si, KR;

Jae-seong Shim, Daejeon, KR;

Eun-kyoung Kwon, Daejeon, KR;

Yong-han Choi, Daejeon, KR;

Inventors:

Chul-Hwan Kim, Daejeon, KR;

Seung-Hak Ko, Gunsan-si, KR;

Jae-Seong Shim, Daejeon, KR;

Eun-Kyoung Kwon, Daejeon, KR;

Yong-Han Choi, Daejeon, KR;

Assignee:

BIOGENICS, INC., Daejeon, KR;

Attorneys:

IPLA P.A.

James E. Bame

Primary Examiner:

Bethany Barham

Assistant Examiner:

Dominic Lazaro

Int. Cl.
CPC ...
A61K 9/48 (2006.01); C08J 3/12 (2006.01); C08L 3/02 (2006.01); A61K 31/00 (2006.01); A61K 36/25 (2006.01); A61K 36/16 (2006.01); A61K 31/201 (2006.01); A61K 31/19 (2006.01); A61K 31/355 (2006.01); C07C 57/03 (2006.01); A61K 31/385 (2006.01); A61K 31/52 (2006.01); C08L 1/02 (2006.01); C08L 1/28 (2006.01); C08L 5/00 (2006.01); C08L 5/04 (2006.01); C08L 5/06 (2006.01); C08L 5/12 (2006.01); C08L 5/08 (2006.01);
U.S. Cl.
CPC ...
C08J 3/126 (2013.01); A61K 31/00 (2013.01); A61K 31/19 (2013.01); A61K 31/201 (2013.01); A61K 31/355 (2013.01); A61K 31/385 (2013.01); A61K 31/52 (2013.01); A61K 36/16 (2013.01); A61K 36/25 (2013.01); C07C 57/03 (2013.01); C08L 1/02 (2013.01); C08L 1/286 (2013.01); C08L 3/02 (2013.01); C08L 5/00 (2013.01); C08L 5/04 (2013.01); C08L 5/06 (2013.01); C08L 5/12 (2013.01); C08L 5/08 (2013.01);
Abstract

Provided is a method of solubilizing a poorly soluble/insoluble active material through formation of an oligomer composite, in which a structure having a hydrophobic cavity structure is formed by using oligomers derived from two types of hydrophilic natural polymers and a poorly soluble/insoluble component is encapsulated in the cavity structure, and thus, self-aggregation of the poorly soluble/insoluble material is prevented and simultaneously, thermodynamic stability increases to effectively solubilize the poorly soluble/insoluble material. According to the constitution of the present invention, the method may include a first operation of preparing an oligomer composite having a cavity structure formed therein by mixing and dissolving oligomers derived from two types of hydrophilic natural polymers in water, and a second operation of adding a poorly soluble/insoluble material to the oligomer composite to encapsulate the poorly soluble/insoluble material in the hydrophobic cavity structure of the oligomer composite.

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