The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Jul. 09, 2013
Amgen Inc., Thousand Oaks, CA (US);
Hosung Min, Newbury Park, CA (US);
Hailing Hsu, Moorpark, CA (US);
Fei Xiong, Thousand Oaks, CA (US);
Amgen Inc., Tousand Oaks, CA (US);
Abstract
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence DzLzwherein zis an amino acid residue and zis threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula(X)—V—(X)wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.