The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2015

Filed:

Jun. 19, 2012
Applicants:

Jianjie MA, Belle Mead, NJ (US);

Noah Weisleder, Elizabeth, NJ (US);

Chuanxi Cai, Louisville, KY (US);

Inventors:

Jianjie Ma, Belle Mead, NJ (US);

Noah Weisleder, Elizabeth, NJ (US);

Chuanxi Cai, Louisville, KY (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12N 15/63 (2006.01); C12N 5/10 (2006.01); C07H 21/04 (2006.01); C07K 14/435 (2006.01); C07K 14/475 (2006.01); C07K 14/47 (2006.01); A01K 67/027 (2006.01); C07K 16/18 (2006.01); C12N 15/85 (2006.01); C40B 30/06 (2006.01); C40B 40/02 (2006.01); C12N 15/86 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4702 (2013.01); A01K 67/0276 (2013.01); C07H 21/04 (2013.01); C07K 16/18 (2013.01); C12N 15/85 (2013.01); C12N 15/8509 (2013.01); C40B 30/06 (2013.01); C40B 40/02 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); C07K 14/435 (2013.01); C07K 14/475 (2013.01); C07K 2319/10 (2013.01); C07K 2319/21 (2013.01); C07K 2319/24 (2013.01); C07K 2319/35 (2013.01); C12N 5/00 (2013.01); C12N 15/09 (2013.01); C12N 15/63 (2013.01); C12N 15/86 (2013.01); C12N 2310/351 (2013.01); C12N 2800/22 (2013.01);
Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. In particular, the present invention provides nucleic acid molecules that include optimization features that enhance the expression and/or recovery and/or activity of encoded polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.


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