The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Mar. 08, 2012
Applicants:
Thomas E. Jenkins, Half Moon Bay, CA (US);
Craig O. Husfeld, San Mateo, CA (US);
Inventors:
Thomas E. Jenkins, Half Moon Bay, CA (US);
Craig O. Husfeld, San Mateo, CA (US);
Assignee:
Signature Therapeutics, Inc., Palo Alto, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/00 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); A61K 38/05 (2006.01); A61K 38/06 (2006.01); A61K 45/06 (2006.01); C07K 5/08 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); A61K 45/06 (2013.01); C07K 5/06026 (2013.01); C07K 5/08 (2013.01); A61K 38/00 (2013.01);
Abstract
The embodiments provide prodrug compounds of Formulae I-XVII. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of Formulae I-XVII that provides controlled release of an active agent. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of an active agent from the prodrug so as to attenuate enzymatic cleavage of the prodrug.