The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Jul. 04, 2012
Yong Wang, Nanjing, CN;
Cang Zhang, Nanjing, CN;
Xiaorong Liu, Nanjing, CN;
Yan Zhang, Nanjing, CN;
Yunyun Wang, Nanjing, CN;
Wenping Zhang, Nanjing, CN;
Yong Wang, Nanjing, CN;
Cang Zhang, Nanjing, CN;
Xiaorong Liu, Nanjing, CN;
Yan Zhang, Nanjing, CN;
Yunyun Wang, Nanjing, CN;
Wenping Zhang, Nanjing, CN;
Nanjing Sanhome Pharmaceutical Co., Ltd., Nanjing, CN;
Abstract
The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.