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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9138474 B1

PDFFull Text
Date of Patent:
Sep. 22, 2015

Filed:

Oct. 04, 2013

Composition comprising expression or activity inhibitors of ninjurin1 for the prevention and treatment of inflammatory disease

Applicant:

Snu R&db Foundation, Seoul, KR;

Inventors:

Kyu-Won Kim, Seoul, KR;

Hyo-Jong Lee, Seoul, KR;

Bum Ju Ahn, Seoul, KR;

Assignee:

SNU R&DB FOUNDATION, Seoul, KR;

Attorney:

Lucas & Mercanti, LLP

Primary Examiner:

Sean McGarry

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 31/00 (2006.01); A61K 31/713 (2006.01); A61K 38/17 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 15/113 (2010.01); G01N 33/50 (2006.01); A61K 38/02 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 31/00 (2013.01); A61K 31/713 (2013.01); A61K 38/02 (2013.01); A61K 38/1709 (2013.01); C07K 14/705 (2013.01); C07K 16/28 (2013.01); C12N 15/1138 (2013.01); G01N 33/5023 (2013.01); C07K 2317/76 (2013.01); C12N 2310/14 (2013.01); G01N 2800/102 (2013.01); G01N 2800/205 (2013.01); G01N 2800/285 (2013.01); G01N 2800/323 (2013.01);
Abstract

The present invention relates to a composition comprising a Ninjurin1 expression or activity inhibitor for the prevention and treatment of inflammatory disease. Ninjurin1 protein is specifically expressed in macrophages around blood vessels, increases cell-cell adhesion and cell-matrix adhesion, increases expressions of Wntb (Wingless-type MMTV integration site family, memberB) and Ang(angiopoietin-2), but reduces expression of Angto induce apoptosis of vascular endothelial cells. In addition, Ninjurin1 protein is up-regulated when inflammation is induced and induces iNOS expression as well as increased NO generation. Therefore, the Ninjurin1 protein expression or activation inhibitor can be effectively used as an active ingredient of a composition for the prevention and treatment of inflammatory disease.

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