The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2015
Filed:
Jul. 29, 2009
Jan Huisken, Dresden, DE;
Jan Huisken, Dresden, DE;
The Regents of the University of California, Oakland, CA (US);
Abstract
A method and device for multi-directional selective plane illumination microscopy is provided. A detector focal plane is alternately illuminated with at least two counter-propagating, coplanar light sheets, and an image of a specimen cross-section positioned in the focal plane is detected while only one light sheet illuminates the specimen. The wavefront of the illumination beams may be deformed with adaptive optics using feedback from light transmitted through the specimen. Multiple images of the specimen cross-section may be detected at different times and specimen positions and orientations to produce multi-view image stacks which may be processed using image fusion to produce a reconstructed image representation of the specimen. Additionally, the direction of propagation of the alternating light sheets may be pivoted in the focal plane while detecting the image.