The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2015
Filed:
Dec. 04, 2012
Applicants:
John J. Nemunaitis, Cedar Hill, TX (US);
Donald Rao, Dallas, TX (US);
F. Charles Brunicardi, Pacific Palisades, CA (US);
Inventors:
John J. Nemunaitis, Cedar Hill, TX (US);
Donald Rao, Dallas, TX (US);
F. Charles Brunicardi, Pacific Palisades, CA (US);
Assignees:
Strike Bio, Inc., Dallas, TX (US);
Baylor College of Medicine, Houston, TX (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); A61K 9/127 (2006.01); C07H 21/02 (2006.01); A61K 48/00 (2006.01); C12N 15/113 (2010.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); C12N 15/85 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2330/51 (2013.01);
Abstract
A bifunctional shRNA-based composition and methods for knocking down the expression of the PDX-1 oncogene in target cells is described herein. The invention also provides methods to deliver the shRNA-containing expression vectors to target tissues overexpressing the PDX-1 oncogene.