The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2015

Filed:

Jun. 05, 2013
Applicant:

Cyclacel Limited, London, GB;

Inventors:

Jonathan James Hollick, Perth, GB;

Stuart Donald Jones, Cheshire, GB;

Claire June Flynn, Angus, GB;

Michael George Thomas, Braco, GB;

Assignee:

Cyclacel Limited, London, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/551 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); C07D 453/02 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 453/02 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention relates to a compound of formula (VII)I, or pharmaceutically acceptable salt or ester thereof, wherein: X is NR; Y is O or N—(CH)R; n is 1, 2 or 3; m is 1 or 2; Rand Rare each independently H, alkyl or cycloalkyl; Rand Rare each independently H or alkyl; or Rand Rtogether form a spiro cycloalkyl group; Ris H, alkyl, aryl or a cycloalkyl group; Ris ORor halogen; and Rand Rare each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.


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