The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2015

Filed:

Feb. 28, 2012
Applicants:

James F. Blake, Boulder, CO (US);

Huifen Chen, South San Francisco, CA (US);

Mark Joseph Chicarelli, Boulder, CO (US);

Jason Demeese, Boulder, CO (US);

Rustam Garrey, Boulder, CO (US);

John J. Gaudino, Boulder, CO (US);

Robert J. Kaus, Boulder, CO (US);

Gabrielle R. Kolakowski, Boulder, CO (US);

Allison L. Marlow, Boulder, CO (US);

Peter J. Mohr, Boulder, CO (US);

LI Ren, Boulder, CO (US);

Jacob Schwarz, South San Francisco, CA (US);

Christopher S. Siedem, Boulder, CO (US);

Allen A. Thomas, Boulder, CO (US);

Eli Wallace, Boulder, CO (US);

Steven Mark Wenglowsky, Boulder, CO (US);

Steven Boyd, Boulder, CO (US);

Inventors:

James F. Blake, Boulder, CO (US);

Huifen Chen, South San Francisco, CA (US);

Mark Joseph Chicarelli, Boulder, CO (US);

Jason Demeese, Boulder, CO (US);

Rustam Garrey, Boulder, CO (US);

John J. Gaudino, Boulder, CO (US);

Robert J. Kaus, Boulder, CO (US);

Gabrielle R. Kolakowski, Boulder, CO (US);

Allison L. Marlow, Boulder, CO (US);

Peter J. Mohr, Boulder, CO (US);

Li Ren, Boulder, CO (US);

Jacob Schwarz, South San Francisco, CA (US);

Christopher S. Siedem, Boulder, CO (US);

Allen A. Thomas, Boulder, CO (US);

Eli Wallace, Boulder, CO (US);

Steven Mark Wenglowsky, Boulder, CO (US);

Steven Boyd, Boulder, CO (US);

Assignees:

ARRAY BIOPHARMA INC., Boulder, CO (US);

GENENTECH, INC., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/90 (2006.01); A61K 31/519 (2006.01); C07D 487/00 (2006.01); C07D 471/04 (2006.01); C07D 491/052 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); C07D 491/052 (2013.01);
Abstract

Compounds having the formula I wherein Z, ZZZ, R, Rand Rand as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.


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