The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2015
Filed:
Mar. 12, 2013
Oncomed Pharmaceuticals, Inc., Redwood City, CA (US);
Edward Thein Htun van der Horst, Palo Alto, CA (US);
Austin L. Gurney, San Francisco, CA (US);
Timothy Charles Hoey, Hillsborough, CA (US);
Maureen Fitch Bruhns, San Mateo, CA (US);
Fumiko Takada Axelrod, Palo Alto, CA (US);
OncoMed Pharmaceuticals, Inc., Redwood City, CA (US);
Abstract
The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.