The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2015

Filed:

Feb. 13, 2012
Applicants:

Kamesh R. Sirigireddy, Worthington, MN (US);

Paulraj K. Lawrence, Worthington, MN (US);

Russell F. Bey, Worthington, MN (US);

Randy R. Simonson, Worthington, MN (US);

Inventors:

Kamesh R. Sirigireddy, Worthington, MN (US);

Paulraj K. Lawrence, Worthington, MN (US);

Russell F. Bey, Worthington, MN (US);

Randy R. Simonson, Worthington, MN (US);

Assignee:

NEWPORT LABORATORIES, Worthington, MN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/102 (2006.01); A61K 39/00 (2006.01); C12R 1/21 (2006.01); C07K 14/285 (2006.01); C12N 9/12 (2006.01); C12N 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 39/102 (2013.01); C07K 14/285 (2013.01); C12N 9/1205 (2013.01); C12N 9/14 (2013.01); C12R 1/21 (2013.01); C12Y 207/01059 (2013.01); C12Y 306/03014 (2013.01); A61K 2039/522 (2013.01); A61K 2039/542 (2013.01); A61K 2039/552 (2013.01);
Abstract

The present invention is a live vaccine from a culture of cells ofexhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth. Several SNPs have been identified as associated with specific proteins that are associated with virulence as seen in the literature inor related bacterial species.


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