The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2015
Filed:
May. 14, 2010
Noëlle Mistretta, Sain Bel, FR;
Monique Moreau, Lyons, FR;
Geneviève Renauld-mongenie, Chaponost, FR;
Bachra Rokbi, Lyons, FR;
Noëlle Mistretta, Sain Bel, FR;
Monique Moreau, Lyons, FR;
Geneviève Renauld-Mongenie, Chaponost, FR;
Bachra Rokbi, Lyons, FR;
Sanofi Pasteur SA, Lyons, FR;
Abstract
The invention especially relates to multivalent vaccine compositions that can treat or prevent at least 60, preferably 75% of infections caused byespecially of serogroup B. To this end, the invention in particular provides a lipooligosaccharide (LOS) ofin particular constituted by a lipid A, an inner core, an α chain of L6 or L8 type, in which the heptose II residue of the inner core bears in position O-3 and in position O-6 or O-7 a phosphoethanolamine (PEA) substituent, and also to the construction of the strain ofthat is capable of expressing such an LOS. The invention also relates to a strain ofof serogroup A that bears a lipooligosaccharide (LOS) in particular constituted by a lipid A, an inner core, an α chain of L6 type, in which the heptose II residue of the inner core bears in position O-3 a phosphoethanolamine (PEA) substituent and does not bear a PEA substituent in positions O-6 and O-7. The LOSs cited or originating from the mentioned strains may be used as vaccine antigens, especially in multivalent, e.g. divalent compositions, so as to offer protection against the major epidemiological complexes of, especially of serogroup B.