The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2015
Filed:
Dec. 20, 2010
John J. Nemunaitis, Cedar Hill, TX (US);
Neil Senzer, Dallas, TX (US);
Phillip B. Maples, Pilot Point, TX (US);
Donald Rao, Dallas, TX (US);
John J. Nemunaitis, Cedar Hill, TX (US);
Neil Senzer, Dallas, TX (US);
Phillip B. Maples, Pilot Point, TX (US);
Donald Rao, Dallas, TX (US);
GRADALIS, INC., Dallas, TX (US);
Abstract
Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.