The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2015
Filed:
Feb. 28, 2013
Chang Gung University, Tao-Yuan, TW;
Jiun-Jie Wang, Guishan Township, Taoyuan County, TW;
Yu-Chun Lin, Guishan Township, Taoyuan County, TW;
Tsung-Han Chan, Hsinchu, TW;
Chong-Yung Chi, Baoshan Township, Hsinchu County, TW;
Shu-Hang Ng, Guishan Township, Taoyuan County, TW;
Yau-Yau Wai, Guishan Township, Taoyuan Couny, TW;
Chang Gung University, Tao-Yuan, TW;
Abstract
The present invention discloses a method for extracting AIF and an application thereof to DCE-MRI. The method comprises steps: contacting a target tissue with a contrast agent to obtain a plurality of images; using the plurality of images to work out the tissue concentration curve of the contrast agent in each voxel; calculating the purity of the tissue concentration curve of each voxel according to the tissue concentration curves; and extracting the voxel having the highest purity as the optimized arterial location; and extracting the tissue concentration curve of the voxel having the highest purity as the arterial input function. The extracted AIF is applied to a pharmacokinetic model to obtain associated pharmacokinetic parameters. The present invention not only improves the accuracy and reliability of the derived quantitative indexes but also promotes the efficiency of the quantitative analysis.