The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2015

Filed:

Aug. 19, 2013
Applicants:

Kiminobu Sugaya, Winter Park, FL (US);

Angel Alvarez, Chicago, IL (US);

Amelia Marutle, Stockholm, SE;

Inventors:

Kiminobu Sugaya, Winter Park, FL (US);

Angel Alvarez, Chicago, IL (US);

Amelia Marutle, Stockholm, SE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 15/85 (2006.01); C12N 5/077 (2010.01); C12N 15/87 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 5/0657 (2013.01); C12N 15/87 (2013.01); C12N 2501/40 (2013.01); C12N 2506/08 (2013.01); C12N 2510/00 (2013.01);
Abstract

Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.


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