The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2015
Filed:
Jun. 24, 2012
Shiao-chun Tu, Houston, TX (US);
Shiao-Chun Tu, Houston, TX (US);
University of Houston System, Houston, TX (US);
Abstract
The present invention discloses systems and methods for altering the color of bacterial bioluminescence via a fusion protein complex by fusingsp. fluorescent protein mOrange (mOrange) withluciferase. The fusion of mOrange to the N- or C-terminus of either α or β subunit of luciferase, via a short peptide linker produces fully active fusion enzymes. The fusion of mOrange to the N-terminus of luciferase α gives rise to a new 560-nm emission component. The same methodology may be used to alter bacterial bioluminescence color by covalent attachment of other suitable fluorescent proteins or chromophores to luciferase for generating multi-color sensors.
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