The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2015
Filed:
Jan. 12, 2010
Applicants:
Henry Fredric Epstein, Bellaire, TX (US);
Wei Guo, Galveston, TX (US);
Daisi Chen, Galveston, TX (US);
Ram Singh, Lubbock, TX (US);
Inventors:
Henry Fredric Epstein, Bellaire, TX (US);
Wei Guo, Galveston, TX (US);
Daisi Chen, Galveston, TX (US);
Ram Singh, Lubbock, TX (US);
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01); C07K 14/47 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C07K 14/47 (2013.01); G01N 33/574 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01);
Abstract
Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed.