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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9127090 B1

PDFFull Text
Date of Patent:
Sep. 08, 2015

Filed:

Jun. 29, 2011

Artificial antibody polypeptides

Applicant:

Shohei Koide, Rochester, NY (US);

Inventor:

Shohei Koide, Rochester, NY (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:

Viksnins Harris & Padys PLLP

Primary Examiner:

Karen Canella

Int. Cl.
CPC ...
C12N 5/10 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C07K 14/78 (2006.01); C07K 16/00 (2006.01); C12N 15/10 (2006.01); C40B 40/02 (2006.01); G01N 33/68 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); G01N 33/78 (2006.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 16/40 (2013.01); C12N 15/1037 (2013.01); C12N 15/1044 (2013.01); C40B 40/02 (2013.01); G01N 33/68 (2013.01); G01N 33/6845 (2013.01); C07K 2317/565 (2013.01); C07K 2318/20 (2013.01); G01N 33/78 (2013.01); G01N 2333/78 (2013.01);
Abstract

A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, k, and an uncatalyzed rate constant, k, such that the ratio of k/kis greater than 10.

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