The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2015
Filed:
Dec. 11, 2012
Applicant:
Rhodes Technologies, Coventry, RI (US);
Inventors:
Joshua Robert Giguere, Sharon, MA (US);
Keith Edward McCarthy, Old Lyme, CT (US);
Helge Alfred Reisch, Westerly, RI (US);
Sergio Sandoval, West Warwick, RI (US);
Jake Larry Stymiest, Foster, RI (US);
Assignee:
Rhodes Technologies, Coventry, RI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/00 (2006.01); C07D 489/08 (2006.01); C07C 209/00 (2006.01); C07C 269/04 (2006.01); C07D 265/30 (2006.01); C07C 209/44 (2006.01);
U.S. Cl.
CPC ...
C07D 489/08 (2013.01); C07C 209/00 (2013.01); C07C 209/44 (2013.01); C07C 269/04 (2013.01); C07D 265/30 (2013.01);
Abstract
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.